France · Administered pricing
The price that didn't move
While England's apixaban price collapsed 95%, France paid the same 59 euros a
box for four years, and the national bill nearly doubled. Administered pricing, in monthly data.
1 cutin 64 months
+86%monthly bill, 2021 to 2026
2 systemsone molecule, opposite outcomes
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Direct oral anticoagulants · England, US & Australia · August 2026
One molecule, three prices
When apixaban lost exclusivity, England's price fell 95% in twelve months and
£354m a year left the drug bill. Australia's fell on a statutory timetable. America's kept rising
for two more years, until Medicare negotiation, not competition, cut it 43% overnight. What one
patent cliff, watched in three pricing systems at once, says about erosion assumptions.
−95%England price, 12 months
170×US vs England, per tablet
3 systemscompetition · statute · disclosure
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GLP-1 receptor agonists · England & US Medicaid · August 2026
What 97% looks like in real prescribing data
England's GLP-1 market nearly tripled in four years. Inside it, liraglutide lost
97% of its volume while tirzepatide went from zero to market leadership in fifteen months, and the same molecules are switching places differently in the US. Why class-level forecasts miss
within-class dynamics, and what that does to a budget impact model.
97%liraglutide volume decline
0 → 215ktirzepatide items/month
2 marketsEngland · US Medicaid
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Where these analyses come from
We maintain a molecule-level database built from national prescribing sources: the NHSBSA English Prescribing Dataset (every primary-care item since 2021, 748 million rows), CMS Medicaid
State Drug Utilization Data (products mapped to molecules via the openFDA NDC directory), and
Australia's PBS date-of-supply data. Launches are aligned on a common clock, coding changes are
filtered from genuine launches, and every figure traces to a published public series. The same
database supplies uptake analogues and erosion curves for client budget impact work.